Takotsubo cardiomyopathy is a relatively rare disease entity with a rapid reversible ventricular dysfunction, which usually occurs in post–menopausal women, and is frequently associated with a stressful event. Diagnosing Takotsubo cardiomyopathy can sometimes be challenging. The absence of coronary artery obstructive disease, and the dramatic presentation of the patient mimicking acute coronary syndrome, make this disease unique. We discuss here a case of Takotsubo cardiomyopathy with extremely rapid resolution in just two days, which we believe is being reported for the first time and touch briefly on the salient features, pathogenesis, diagnosis, treatment, prognosis, and clinical significance of this unique entity.