Epigenetic inheritance: Uncontested?

• 来源期刊: 细胞研究(英文版)
• 学科: 生物学
• 年，卷（期）: 2011,（3）
• 页码范围: 435-441
• 页数: 7页
• 分类号: Q2
• 语种: 中文
• DOI: 10.1038/cr.2011.26

摘要

"Epigenetics" is currently defined as "the inheritance of variation(-genetics)above and beyond(epi-)changes in the DNA sequence". Despite the fact that histones are believed to carry important epigenetic information, little is known about the molecular mechanisms of the inheritance of histone-based epigenetic information, including histone modifications and histone variants. Here we review recent progress and discuss potential models for the mitotic inheritance of histone modifications-based epigenetic information.