从胰腺的 neuroendocrine 癌的胸和肺转移

• 作者: Eddie W Manning Ⅲ Joe Levi Joshua Palmer Shevonne Satahoo-Dawes
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: NEUROENDOCRINE TUMOR METASTATIC TUMOR PANCREATIC TUMOR BREAST Lung
• 年，卷（期）: 2011,（1）
• 页码范围: 32-37
• 页数: 6页
• 分类号: R734.2

摘要

Pancreatic neuroendocrine tumors(PNETs) are an uncommon malignancy,accounting for a small percentage of all pancreatic malignancies.Due to their insidious course,most PNETs present with metastatic disease.Although reports in the literature describe PNET metastasis to the liver,lung and brain,to date there are no reports of stage Ⅳ disease involving the breast.Moreover,the lack of consensus regarding classification and treatment of this entity leaves practitioners without standards of practice or a firm base from which to formulate prognosis.In this report,the case of a previously healthy 51-year-old woman with stage Ⅳ PNET is examined.After combined neoadjuvant therapy with 5-fluorouracil,carboplatin,etoposide and radiation,surgical resection revealed metastatic PNET to the breast and lung,with no microscopic evidence of residual disease within the pancreas.An extensive analysis of the presentation,diagnosis,imaging modalities,treatment options,and prognosis is included in the discussion.As demonstrated by our review,there is a need for further studies to delineate inconclusive evidence with respect to subtype classification,treatment and prognosis of PNETs.