Does a melatonin supplement alter the course of gastroesophageal reflux disease?

• 作者: Mariusz H Madalinski
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Gastro-esophageal REFLUX disease MELATONIN CHEMOPROTECTION Barrett’s
• 年，卷（期）: 2011,（6）
• 页码范围: 50-51
• 页数: 2页
• 分类号: R571

摘要

Symptomatic gastro-esophageal reflux disease(GERD) is a very common disease.The consequence of GERD is not only erosive esophagitis,but also esophageal stricture,Barrett’s esophagus and extra-esophageal damage(including the lungs,throat,sinuses,middle ear and teeth).GERD and Barrett’s esophagus are also identif ied as major risk factors for esophageal carcinoma.Therapy with melatonin prevents esophageal injury from acid-pepsin and acid-pepsin-bile exposure in animals,then further studies are required in humans to establish whether a melatonin supplement is able to protect the patients with GERD from erosions,Barrett’s and neoplasia.