为为在诺思非洲的 hepatocellular 癌开发的风险因素的第一 multicenter 研究

• 作者: Abdallah Essaid El Feydi Agnes Marchio Anne Dejean Fella Iguer Hafedh Mestiri Hinda Triki Latifa Elkihal Moustapha Benazzouz Nabil Debzi Nissaf Ben Alaya-Bouafif Olfa Bahri Pascal Pineau Rajaa Afifi Salah Berkane Sayeh Ezzikouri Soumaya Benjelloun Tahar Khalfallah
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: HEPATOCELLULAR carcinoma HEPATITIS B VIRUS HEPATITIS C VIRUS NON-INSULIN-DEPENDENT diabetes mellitus North Africa
• 年，卷（期）: 2011,（1）
• 页码范围: 24-30
• 页数: 7页
• 分类号: R735.7

摘要

AIM:To assess the role of the major risk factors for hepatocellular carcinoma(HCC) development in the western part of North Africa.METHODS:A multicenter case control study was conducted in Tunisia,Morocco and Algeria in collaboration with Pasteur Institutes in these countries.A total of 164 patients with HCC and 250 control subjects without hepatic diseases were included.Prevalences of HBsAg,anti-hepatitis C virus(HCV)and diabetes were assessed.HCV and HBV genotyping were performed for anti-HCV and HBsAg positive patients.RESULTS:The mean age of patients was 62±10 years old for a 1.5 M:F sex ratio.Sixty percent of HCC patients were positive for anti-HCV and 17.9% for HBsAg.Diabetes was detected in 18% of cases.Odd ratio(OR)and 95% confidence intervals(CI) were 32.0(15.8-65.0),7.2(3.2-16.1) and 8.0(3.1 -20.0)for anti-HCV,HBsAg and diabetes respectively.Multivariate analysis indicated that the three studied factors were independent.1b HCV genotype and D HBV genotype were predominant in HCC patients.HCV was the only risk factor significantly associated with an excess of cirrhosis(90% vs 68% for all other risk factors collectively,P=0.00168).Excessive alcohol consumption was reliably established for 19(17.6%) cases among the 108 HCC patients for whom data is available.CONCLUSION:HCV and HBV infections and diabetes are the main determinants of HCC development in North Africa.An active surveillance and secondary prevention programs for patients with chronic hepatitis and nutrition-associated metabolic liver diseases are the most important steps to reduce the risk of HCC in the region.Salah Berkane,Department of Gastroenterology BologhineUniversity Hospital,Bologhine 16090,Algiers,Algeria