Rate Enhancements in the Acetylation and Benzoylation of Certain Aromatic Compounds with Vilsmeier-Haack Reagents Using Acetamide, Benzamide and Oxychlorides under Non-Conventional Conditions

• 作者: Kamatala Chinna Rajanna Marri Venkateswarlu Mukka Satish Kumar Pondichery Kuppuswamy Saiprakash Soma Ramgopal Utkoor Umesh Kumar
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: ACETYLATION BENZOYLATION Vilsmeier-Haack REAGENT (VHR) ACETAMIDE BENZAMIDE Micro Wave Irradiation Grinding Sonication
• 年，卷（期）: 2011,（4）
• 页码范围: 233-241
• 页数: 9页
• 分类号: O6

摘要

Acetylation and benzoylation reactions of certain aromatic aldehydes, ketones with Vilsmeier-Haack Re- agents using Acetamide and Oxychloride (SOCl2 or POCl3) under conventional (thermal) and non conven- tional [microwave irradiated (MIR), ultrasonic assisted and solvent free mortar pestle (grinding)] conditions. Reactions afforded good to excellent yields of products with both the VH reagents, reaction times were fairly less in the case of [amide/POCl3] than those of [amide/SOCl2] reagent. Reactions are dramatically acceler- ated in under sonicated and microwave irradiations with a trend: MIR (few seconds) >> Sonication (minutes) > Grinding (min) >> thermal (several hrs).