miRNA and nasopharyngeal carcinoma

• 来源期刊: 科学通报(英文版)
• 学科: 医学
• 关键词: miRNAs 鼻咽癌 非编码RNA 小分子RNA 信号转导通路 潜伏膜蛋白1 基因调控网络 肿瘤血管生成
• 年，卷（期）: 2011,（8）
• 页码范围: 722-728
• 页数: 7页
• 分类号: R739.63
• 语种: 中文

摘要

MicroRNAs(miRNAs) constitute a family of small non-coding RNA molecules 22-25 nucleotides in length.miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3'-untranslated regions.Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma,such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways,gene-regulatory networks,mitosis,tumor angiogenesis,invasion and migration.Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma,will further the understanding of this cancer and provide new avenues for diagnosis and treatment.