Understanding the Glycoproteins Release from Alginate-Barium Capsules in Physiologic Enviroments

• 作者: Edgar Perez Herrero Eva M. Martin del Valle Miguel A. Galán
• 来源期刊: 化学工程与科学期刊(英文)
• 学科: 医学
• 关键词: Controlled RELEASE Systems Proteins GLYCOPROTEINS Growth Factors Mass Transfer Unsteady Steady
• 年，卷（期）: 2011,（4）
• 页码范围: 256-270
• 页数: 15页
• 分类号: R73

摘要

The authors carried out a steady and unsteady mass transfer studies to simulate both the release of proteins in physiologic environments and proteins transport through a tissue or organ from polymeric capsules by using a substance, the rhodamine B isothiocyanate dextran (RBID) that mimics the behaviour of glycoproteins such as vascular endothelial growth factor (VEFG). These studies highlighted the importance of electrostatic interactions between alginate and proteins in the release processes. Thereby, this fact has opened new perspectives in order to use these kind of capsules in protein recognition processes. The electrostatic interactions between alginate and RBID allow pH-dependent controlled release systems that simulate the behaviour of glycoproteins.