Ductopenia 相关的肝肉状瘤

• 作者: Alain Cazier Ali Mofredj Jean-Franois D Cadranel Maria Lahmiri Nourr-Eddine Farouj Pierre LeLann Vincent Jouannaud
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: SARCOIDOSIS CHOLESTASIS ductopenia Ursodeoxycholic ACID
• 年，卷（期）: 2011,（6）
• 页码范围: 170-174
• 页数: 5页
• 分类号: R575

摘要

Sarcoidosis is a systemic granulomatous disease which may involve many organs.In approximately 95% of patients there is liver involvement,with noncaseating hepatic granulomas occurring in 21 to 99% of patients with sarcoidosis.Liver involvement is usually asymptomatic and limited to mild to moderate abnormalities in liver biochemistry.The occurrence of jaundice in sarcoidosis is rare;extensive imaging procedures and the examination of liver biopsies permit a precise diagnostic.Ductopenia associated with sarcoidosis has been reported in less than 20 cases and can lead to biliary cirrhosis and liver-related death.We report here on a case of ductopenia-related sarcoidosis in which primary biliary cirrhosis and extrahepatic cholestasis have been carefully excluded.The patient follow up was 8 years.Although ursodesoxycholic acid appears to improve liver biochemistry it does not preclude the rapid occurrence of extensive fibrosis.A review of the literature of reported cases of ductopenia related to sarcoidosis is provided.