A lincRNA switch for embryonic stem cell fate

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（12）
• 页码范围: 1646-1648
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2011.166

摘要

Cumulative evidences have demonstrated that most of the non-repetitive genome in higher organisms are actively transcribed and surprisingly only a small percentage (＜ 20％) of transcripts are associated with genes that encode proteins [1].One of the emerging themes in the study of non-coding transcripts is large intergenic non-coding RNAs (lincRNAs),a class of large regulatory RNAs implicated in imprinting,dosage compensation,and transcriptional regulation [2].In light of recent discoveries revealing the flexibility of lincRNAs and their abilities to act as modular scaffolds for protein-chromatin interactions and to form spatially compact arrays of complexes [3,4],many would acknowledge that most lincRNAs act as sensors and integrators of a wide variety of regulated transcriptional responses and probably epigenetic events,which may have an impact on various human diseases.