在规划 death-1 基因的多型性没在中国病人与长期的 HBV 感染被联系

• 作者: Feng Lv, Yu-Feng Gao, Zhen-Huan Zhang, Tian-Chen Zhang, Fa-Ming Pan, Ming-Fang Cui, Shu-Ling Xia, Xu Li, Hua-Fa Yin
• 来源期刊: 世界肝病学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Programmed death-1 HEPATITIS B virus Single NUCLEOTIDE POLYMORPHISM Genetic ASSOCIATION study FAMILY-BASED ASSOCIATION test
• 年，卷（期）: 2011,（3）
• 页码范围: 72-78
• 页数: 7页
• 分类号: R512.62

摘要

AIM:To investigate the association between the programmed death-1(PD-1) polymorphisms and genetic susceptibility of chronic hepatitis B virus(HBV) infection in Chinese patients.METHODS:Two single nucleotide polymorphisms(SNPs),PD-1.1 G 】 A and PD-1.2 G 】 A,were genotyped in 539 patients with chronic HBV infection and 353 other family members(HbsAg-) from 256 nuclear families using polymerase chain reactiorestriction fragment length polymorphisms assay.The associations between PD-1 polymorphisms and genetic susceptibilityof chronic HBV infection were analyzed usng the familybased association analysis method.RESULTS:No association or linkage was detected among 539 patients.Univariate(single-marker) familybased association tests demonstrated that PD-1 genotypes,alleles and transmitted haplotypes are not associated with chronic HBV infection(all with P value more than 0.05).Transmission/disequilibrium test and sibship disequilibrium test analysis showed no excess of the alleles from heterozygous parents to affected offspring(P = 0.688880,P = 1.000000 respectively).CONCLUSION:The data demonstrated that PD-1.1 and PD-1.2 polymorphisms are not associated with chronic HBV infection in Chinese patients.