Bmil puSHHes reprogramming

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（9）
• 页码范围: 1277-1278
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2011.126

摘要

In 2006,the group of Shinya Yamanaka demonstrated that somatic cells could be reprogrammed into induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors associated to stemness:Oct4,Sox2,Klf4 and c-Myc [1].This groundbreaking discovery opened the possibility of generating patient-specific cells for research,drug development and regenerative medicine.Due to the tremendous potential of its clinical applications,understanding the process of reprogramming has become a priority and one of the most fascinating biomedical research topics.