Effect of the water extract of Macrosolen cochinchinensis (Lour.) Tiegh.leaves on7,12-dimethylbenz [a] antracene induced female mice liver carcinogensis

• 作者: Adam Hermawan Edy Meiyanto Nina Artant Retno urwanti
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2011,（6）
• 所属期刊栏目: 简报
• 页码范围: 627-632
• 页数: 6页
• 分类号: R965
• 语种: 英文
• DOI: 10.5246/jcps.2011.06.081

摘要

Liver cancer is the third most common cause of death from cancer worldwide.Recently,natural products were used widely as an alternative therapy for liver cancer.Previous study reported Macrosolen cochnichinensis (Lour.) Tiegh.that grows in the host star fruit inhibited breast cancer cells growth in vitro.This study aims to observe the effect of water extract of M.cochinchinensis leaves (MCE) on Balb/c mice hepatocyte after initiation of 7,12-dimethylbenz [a] anthracene (DMBA) as a liver cancer model inducer.The experiment consisted of four mice groups,corn oil solvent control group,the DMBA dose 20 mg/kgBW p.o.ten times twice a week,DMBA+MCE dose 250 mg/kgBW,and DMBA+MCE 750 mg/kgBW.Extract which was dissolved into 0.5％ CMC-Na was administered daily by the oral route 1 week before,during and terminated 1 week after the DMBA induction.At the end of the study,rat livers were collected and stained with Haematoxyllene and Eosin (H&E) method.Administration of MCE could not inhibit hepatic carcinogenesis in DMBA-induced female mice.There was no difference in liver tissue histopathology profile between the extract treatment group and DMBA control group.