Turning skin into dopamine neurons

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（10）
• 页码范围: 1386-1387
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/cr.2011.130

摘要

The possibility to generate neurons from fibroblasts became a reality with the development of iPS technology a few years ago.By reprogramming somatic cells using transcription factor (TF) overexpression,it is possible to generate pluripotent stem cells that then can be differentiated into any somatic cell type including various subtypes of neurons.This raises the possibility of using donor-matched or even patientspecific cells for cell therapy of neurological disorders such as Parkinson's disease (PD),Huntington's disease and stroke.Supporting this idea,dopamine neurons,which are the cells dying in PD,derived from human iPS cells have been demonstrated to survive transplantation and reverse motor symptoms in animal models of PD [1].