在由 erigeron breviscapus 摘录的固执地提高的 intraocular 压力的 multifocal 网膜电图上的效果

• 作者: Jun-Guo Duan Xue-Jing Lu,
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: ERIGERON breviscapus extract GLAUCOMA MULTIFOCAL ELECTRORETINOGRAM optic NEUROPROTECTION
• 年，卷（期）: 2011,（4）
• 页码范围: 349-352
• 页数: 4页
• 分类号: R285.5

摘要

AIM: To observe the effect on multifocal electroretinogram (mfERG) in persistently elevated intraocular pressure (IOP) by erigeron breviscapus extract (also named Dengzhanhua in Chinese) in rat models. METHODS: The rat models with persistently elevated IOP were established by the method of Akira. Then, erigeron breviscapus extract was given for one month to observe the effect on mfERG in persistently elevated IOP in rats. RESULTS: As elevated IOP went on, the mfERG changes were mainly in weaken of reaction density with progressive development. After intervention of erigeron breviscapus extract, the total peak latency of P1 wave had recovered to some extent and the difference was significant when compared with control group (P 【0.05); the total response density and P1 wave response density in second circle had risen noticeably, which had significant differences than those of control group (P 【0.05). CONCLUSION: Erigeron breviscapus extract can improve the impaired visual function of persistently elevated IOP in rats, suggesting that this extract is the effective part of erigeron breviscapus for optic neuroprotection.