Acylation of nitriles to β-ketonitriles catalyzed by a heterometallic alkoxide cluster of neodymium and sodium:NdNa_8(O~tBu)_(10)(OH)

• 来源期刊: 科学通报(英文版)
• 学科: 化学
• 年，卷（期）: 2011,（13）
• 页码范围: 1357-1360
• 页数: 4页
• 分类号: O643.32
• 语种: 中文

摘要

Catalytic acylation of nitriles with esters in the presence of 10 mol%NdNa8(OtBu)10(OH) is developed.The procedure is suitable for both enolizable and nonenolizable esters and affords β-ketonitriles in moderate to high yields.The heterometallic alkoxide cluster NdNa8(OtBu)10(OH) is structurally characterized by X-ray diffraction,and a mechanism for the production of β-ketonitriles using the cluster is proposed and verified.