Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2011,（8）
• 页码范围: 1262-1266
• 页数: 5页
• 语种: 英文
• DOI: 10.1038/cr.2011.105

摘要

Dear Editor, Males-absent-on-the-first (MOF, also called MYST1 or KAT8) is a histone acetyltransferase (HAT) belonging to the MOZ, Ybf2/Sas3, Sas2 and Tip60 (MYST) family.MOF has been shown to possess a specific HAT activity towards Lysl6 of histone H4 (H4K16) [1].Homozygous knockout of MOF in mice results in loss of H4K16 acetylation and embryonic lethality, indicating that MOF and H4K16 acetylation are essential for embryogenesis and genome stability in mammals [2].Downregulation of human MOF (hMOF) leads to dramatic nuclear morphological deformation and inhibition of cell cycle progression [3], and has recently been correlated with primary breast carcinoma and medulloblastoma [4].