Molecular logic computing model based on self-assembly of DNA nanoparticles

• 来源期刊: 科学通报(英文版)
• 学科: 生物学
• 年，卷（期）: 2011,（33）
• 页码范围: 3566-3571
• 页数: 6页
• 分类号: Q523
• 语种: 中文

摘要

In this paper, a logic computing model was constructed using a DNA nanoparticle, combined with color change technology of DNA/Au nanoparticle conjugates, and DNA computing. Several important technologies are utilized in this molecular computing model: DNA self-assembly, DNA/Au nanoparticle conjugation, and the color change resulting from Au nanoparticle aggregation. The simple logic computing model was realized by a color change, resulting from changing of DNA self-assembly. Based on this computing model, a set of operations computing model was also established, by which a simple logic problem was solved. To enlarge the applications of this logic nanocomputing system, a molecular detection method was developed for H1N1 virus gene detection.