A Case of Cytomegalovirus-Induced Arthritis after Lymphocyte-Depleting Therapy for Kidney Allograft Rejection

• 作者: James Eric Cooper Richard Fuquay
• 来源期刊: 肾脏病(英文)
• 学科: 医学
• 关键词: CYTOMEGALOVIRUS (Mesh) ARTHRITIS (Mesh) Kidney Transplantation (Mesh) Immunosuppression (Mesh) CHEMOPREVENTION (Mesh) VALGANCICLOVIR (Mesh)
• 年，卷（期）: 2012,（1）
• 页码范围: 1-4
• 页数: 4页
• 分类号: R73

摘要

Cytomegalovirus viremia and tissue-invasive disease are common after kidney transplantation. Chemoprophylaxis has made substantial improvement in this clinical problem. Here we report a 29-year-old woman who had kidney allograft rejection and received lymphocyte-depleting therapy. She presented with a new oligo-arthritis that led to 2 successive arthrocenteses. The etiology of the inflammation could not be determined initially. On the second arthrocentesis, a synovial fluid cytomegalovirus polymerase chain reaction test was positive. The patient responded to treatment with valganciclovir, had negative follow-up serum cytomegalovirus polymerase chain reaction tests, and experienced resolution of her joint inflammation. We review briefly the data for cytomegalovirus chemoprophylaxis, preemptive screening, and treatment recommendations.