Effect of oxidative stress on development of silicosis

• 作者: Dao-Kun Zhao En-Qi He Fang Zhou Ping Guo Rong-Ming Miao Xue-Tao Zhang Ying-Yi Zhang
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: SILICOSIS Oxidative stress Superoxide DISMUTASE GLUTATHIONE PEROXIDASE Total antioxidant capacity Nitric oxide SYNTHASE MALONDIALDEHYDE
• 年，卷（期）: 2012,（1）
• 页码范围: 1-5
• 页数: 5页
• 分类号: R

摘要

AIM:To investigate the changes of oxidative stress indicators in the serum of silicosis patients and explore the mechanism of silicosis development.METHODS:Two hundred workers who were exposed to silica dust for more than one year were recruited as dust-exposed group,100 non-dust-exposed subjects served as control group,32 patients with suspected 0+silicosis as observation group,and 130 silicosis patients were taken as the silicosis group.Indicators of oxidative stress,including superoxide dismutase(SOD),nitric oxide(NO),serum glutathione peroxidase(GSHPx),total antioxidant capacity(T-AOC),nitric oxide synthase(NOS),and lipid malondialdehyde(MDA),were determined in all the groups.RESULTS:Compared with the control group,NO and GSH-Px in dust-exposed group and silicosis group increased,and SOD decreased significantly(81.162±35.176,270.469±39.228 and 68.209±21.528,respectively,P=0.004,P=0.002,P=0.005).Compared with the control and dust-exposed group,T-AOC,NOS and MDA in silicosis group increased significantly(13.048±4.153,36.201±7.782 and 5.054±1.204,respectively,P=0.018,P=0.022,P=0.011).Compared with dust-exposed group,GSH-Px in the silicosis group increased significantly(270.469±39.228,P=0.002).GSH-Px in phaseⅢsilicosis was significantly higher than in phaseⅠsilicosis(290.750±39.129,P=0.021).Pearson correlation analysis showed that serum GSH-Px was positively correlated with silicosis staging,length of dust exposure and type of occupation(47.109±8.015,P=0.001).CONCLUSION:The imbalance of oxidative and antioxidation system is associated with the development of silicosis.The surveillance of oxidative stress indicators will benefit the prognosis of silicosis patients.