On the basis of input-output table of Henan Province and China in 2007, this paper advances a simple method of constructing two-region input-output model using MRIO model, to research the economic link between the industries of Henan Province and the industries of other regions. I summarize the characteristics of this method based on this as follows: when researching inter-regional economic link, the multi-region or two-region input-output model has prominent superiority, and we can conduct preliminary estimation on the multi-region input-output model using location quotient approach.