Primary cutaneous anaplastic large cell lymphoma with subsequent leg involvement

• 作者: Hidetoshi Okabe Mitsuaki Ishida Norikazu Fujii
• 来源期刊: 世界皮肤病学杂志
• 学科: 医学
• 关键词: CUTANEOUS LYMPHOMA CUTANEOUS CD30-positive T-cell LYMPHOPROLIFERATIVE lesion PRIMARY CUTANEOUS anaplastic large cell LYMPHOMA LEG INVOLVEMENT Prognosis Chemotherapy
• 年，卷（期）: 2012,（3）
• 页码范围: 38-40
• 页数: 3页
• 分类号: R

摘要

Primary cutaneous anaplastic large cell lymphoma(CALCL)is regarded as an indolent type of cutaneous T-cell lymphoma.However,a few recent publications revealed that C-ALCL patients with initial leg involvement had significantly worse survival than those without initial leg involvement.Herein,we report a case of C-ALCL with subsequent leg involvement,which led to death after chemoradiation therapy.A 75 years old Japanese man presented with multiple erythematous nodules in his left arm and the side of his left chest.Histopathological and immunohistochemical studies led to the diagnosis of primary C-ALCL.At the initial diagnosis,no leg lesion was found.One year after the initial diagnosis,C-ALCL appeared in his right lower thigh and left hip.Radiation therapy,low-dose etoposide and CHOP therapy were performed;however,the patient died of malignant lymphoma 4 years after the initial diagnosis.We speculated that the occurrence of subsequent leg involvement may also be indicative of a worse prognosis,as in the case with initial leg involvement in C-ALCL.Therefore,we propose that C-ALCL patients with initial or subsequent leg involvement should be classified as a distinct clinicopathological variant of C-ALCL(“leg-type”involvement)and that they may require intense therapy.