‘Les liaisons dangereuses’: Hepatitis C, Rituximab and B-cell non-Hodgkin’s lymphomas

• 作者: Adriano M Pellicelli Elia Gigante Emanuela de Santis Gianfranco Delle Fave Ilaria Deli M Christina Cox Massimo Marignani Michela di Fonzo Paola Begini Sara Gallina
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: RITUXIMAB B-CELL non-Hodgkin’s LYMPHOMA Hepatitis C virus IMMUNOCHEMOTHERAPY Methodology
• 年，卷（期）: 2012,（2）
• 页码范围: 21-28
• 页数: 8页
• 分类号: R733.1

摘要

Rituximab has provided a revolutionary contribution to the treatment of B-cell non-Hodgkin’s lymphomas (NHL). A high prevalence of hepatitis C virus (HCV) infection has been described in B-cell NHL patients. Cases of liver dysfunction in HCV-positive patients have been reported with Rituximab-containing regimens. In this paper we review the recent data regarding the effects of Rituximab in NHL patients with HCV infection. We also added a section devoted to improving communication between oncohaematologists and hepatologists. Furthermore, we propose a common methodological ground to study hepatic toxicity emerging during chemotherapy.