Innate and adaptive immune responses against picornaviruses and their counteractions:An overview

• 作者: Andreas Dotzauer Leena Kraemer
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: Picornaviruses and infection POLIOVIRUS Coxsackievirus Human RHINOVIRUS Hepatitis A virus Adaptive IMMUNE SYSTEM INNATE IMMUNE SYSTEM Antibody response and inflammation Apoptosis INTERFERON and cytokines
• 年，卷（期）: 2012,（3）
• 页码范围: 91-107
• 页数: 17页
• 分类号: R

摘要

Picornaviruses,small positive-stranded RNA viruses,cause a wide range of diseases which is based on their differential tissue and cell type tropisms.This diversity is reflected by the immune responses,both innate and adaptive,induced after infection,and the subsequent interactions of the viruses with the immune system.The defense mechanisms of the host and the countermeasures of the virus significantly contribute to the pathogenesis of the infections.Important human pathogens are poliovirus,coxsackievirus,human rhinovirus and hepatitis A virus.These viruses are the beststudied members of the family,and in this review we want to present the major aspects of the reciprocal effects between the immune system and these viruses.