AIM:To study the tear film stability after lamellar keratoplasty.· METHODS:Five female and eight male patients with lamellar keratoconus,aged from 18 to 32,were involved.After lamellar keratoplasty,SchirmerⅠtest(SⅠt),tear break-up time(BUT) test,fluorescein staining test were used to judge the effect of the surgery at different time point.· RESULTS:The SⅠt were greatly increased in 7 days post operation (11.86±2.28-25.14±1.97,19.86±1.61) (P 【0.05),there is no significant difference between 2nd month,3rd month post-operative and pre-operation(11.86±2.28-14.57±1.48,8.14±0.86) (P 】0.05).The mean break-up time decreased in 7 days post operation (5.00±1.31-2.71±0.18,2.57±0.20,2.71±0.36,2.43±0.20)(P 【0.05).The mean scores of fluorescence increased post-operatively (0.14±0.14-8.00±0.00,8.00±0.00,8.00±0.00,7.57±0.20) (P 【0.01).· CONCLUSION:Lamellar keratoplaty influence the tear film stability,artificial tears and improving corneal epithelium cured medicine should be used after surgery.