400 days old chicks were distributed randomly into 4 treatments and 4 replicates in each treatment (25 birds in each replicate) and fed standard feed. The effects of different levels of probiotic in diets for 49 days were studied. Humoral immune responses were studied by conducting experiments on cellular proliferation, entry and survival of beneficial bacteria in gut, immunoglobulin titers. Mean body weight. Gain, feed intake and feed efficiency were recorded significantly (P 8 cfu/g have different immunomodulating effects in broiler chickens.