Modification of the Brief Smell Identification Test by Introduction of a Placebo

• 作者: Asta K. H?berg Grete Kjelvik Linda R. White Liv Heidi Skotnes Ole Bosnes Ragnhild Omli
• 来源期刊: 神经系统科学与医药(英文)
• 学科: 医学
• 关键词: B-SIT ODOR IDENTIFICATION Scratch and Sniff Tests NORWEGIAN Population OLFACTORY Testing NEURODEGENERATIVE Diseases
• 年，卷（期）: 2012,（2）
• 页码范围: 125-129
• 页数: 5页
• 分类号: R73

摘要

Objective: To introduce the concept that there might be “nothing to smell” to the Brief Smell Identification Test (B-SIT), with a view to masking olfactory deficits, particularly from healthy control participants in research studies. Methods: Seventy-one elderly individuals, healthy for their age, were recruited to the study. They were blindfolded and carried out a modified B-SIT where one item had been replaced with a placebo, and one odour alternative answer to three other items was replaced by the alternative “none/other” (actual odour unchanged). Results: There was no overall difference in the median or mean score achieved by the cohort compared to results obtained previously using the conventional B-SIT. The replacement of the item “turpentine” with a placebo resulted in an improved score for the item in a Norwegian setting. The overall scores were not improved. Conclusions: It is possible to introduce the concept that there may be “nothing to smell” to the B-SIT without compromising the test for healthy control individuals. This may be a more appropriate approach to olfactory testing of control individuals or patients with suspected early neurodegenerative diseases.