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摘要:
Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down’s syndrome, have been linked to increased serotonin levels. This work was designed to study changes in serotonin levels in the early stages of development with two classes of antipsychotic drugs: Risperidone, a drug that blocks serotonin and dopamine receptors, and fluoxetine, a serotonin reuptake inhibitor. The use of antipsychotic drugs is a solid choice to study the decrease and increase of these neurotransmitters and their influence on development. The study of these parameters will give an idea of the effects of serotonin in early developmental stages. To this end, we examined the effects of risperidone and fluoxetine on the locomotor activity, heart rate and brain development of zebrafish larvae. Our results showed that in larvae exposed to fluoxetine alone, swimming was significantly increased at 9 dpf (days post-fertilization). Erratic and abnormal movements were observed suggesting a toxic effect of fluoxetine. No erratic swimming was observed in larvae treated with fluoxetine plus risperidone. Both drugs presented morphological changes in dopaminergic neurons and mononeurons. Exposure to fluoxetine plus risperidone indicated possible reversal effects. Studies in zebrafish allow obtaining new insights into the side effects of these drugs as well as into the brain control of locomotor activity. Testing several drug-induced changes in behavior and serotonin levels is one of the experimental approaches for screening a new therapeutically relevant compound, and thus, merits further research.
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篇名 Effect of Risperidone and Fluoxetine on the Movement and Neurochemical Changes of Zebrafish
来源期刊 药物化学期刊(英文) 学科 医学
关键词 ZEBRAFISH RISPERIDONE FLUOXETINE SEROTONIN BEHAVIORAL
年,卷(期) 2012,(4) 所属期刊栏目
研究方向 页码范围 129-138
页数 10页 分类号 R73
字数 语种
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研究主题发展历程
节点文献
ZEBRAFISH
RISPERIDONE
FLUOXETINE
SEROTONIN
BEHAVIORAL
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
药物化学期刊(英文)
季刊
2164-3121
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
64
总下载数(次)
0
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