Synthesis,Crystal Structure and Biological Activity of 2-（Anthracen-9-yl）-5-p-tolyl-1,3,4-oxadiazole

• 作者: HE Dao-Hang LI Xin-Wei
• 来源期刊: 结构化学
• 学科: 农学
• 关键词: 生物活性 晶体结构 恶二唑 甲苯基 合成 单晶X-射线衍射 13C-NMR 蒽
• 年，卷（期）: 2012,（3）
• 页码范围: 367-372
• 页数: 6页
• 分类号: O614.121|S482.39
• 语种: 英文

摘要

A novel compound,2-（anthracen-9-yl）-5-p-tolyl-1,3,4-oxadiazole（C23H16N2O）,has been synthesized by the condensation of 4-methylbenzohydrazide and anthracene-9-carbaldehyde in an ethanol solution with chloramine-T.The compound was characterized by 1H-NMR,13C-NMR,MS and single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P with a = 7.7817（4）,b = 8.8544（5）,c = 12.4726（8） ,β = 92.8520（10）°,Z = 2,V = 826.58（8） 3,Dc = 1.352 g/cm3,Mr = 336.38,λ（MoKα） = 0.71073 ,μ = 0.084 mm-1,F（000） = 352,R = 0.0381 and wR = 0.1099.The dihedral angle between anthracene skeleton and phenyl ring is 64.19°.A total of 6354 unique reflections were collected,of which 3172 with I 〉 2σ（I） were observed.X-ray analysis indicated an offset face-to-face π-π stacking interaction between anthracene skeletons and an offset face-to-face π-π stacking interaction between phenyl ring planes.The novel compound molecules are connected through the offset face-to-face π-π stacking interactions to generate a three-dimensional network.The preliminary bioassay results showed that the novel compound exhibited significant insect growth inhibitory activity against Spodoptera litura Fabricius larvae.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	LI Xin-Wei		1	0	0.0	0.0
2	HE Dao-Hang		1	0	0.0	0.0