Zic3 induces conversion of human fibroblasts to stable neural progenitor-like cells

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 252-255
• 页数: 4页
• 语种: 英文
• DOI: 10.1093/jmcb/mjs015

摘要

Dear Editor, Recent advances in cellular reprogramming have opened the door to the generation of patient-specific cells for regenerative medicine and disease modeling (Takahashi and Yamanaka,2006;Yu et al.,2007;Nakagawa et al.,2008).Apart from OCT4,NANOG,and SOX2,additional transcription factors (TFs) like zinc-finger transcription factor in cerebellum-3 (Zic3) have been shown to play a role in the maintenance of pluripotency (Lim et al.,2007;2010).Zic3,a member of the GLI superfamily,has been implicated in the maintenance of pluripotency in mouse and human embryonic stem cells (ESCs) by directly controlling the expression of Nanog (Lim et al.,2007;2010).Zic3 is also an immediate early gene induced by fibroblast growth factor (FGF) signaling during neural specification (Marchal et al.,2009) and,by preventing neuronal differentiation,plays a role in the maintenance of the neural progenitor cell fate (Inoue et al.,2007).