Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2012,（4）
• 页码范围: 256-257
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/jmcb/mjs032

摘要

Dear Editor, Impaired insulin secretion and insulin resistance are the two main mechanisms that lead to type 2 diabetes mellitus (T2DM).Insulin resistance associated with innate immune system is known to be triggered by the activation of patternrecognition receptors (PRRs) (Olefsky and Glass,2010).Recently,our research group showed that serum ficolin-3,a kind of soluble PRR within the lectin pathway varied significantly between individuals with normal glucose tolerance (NGT) and those with T2DM (Li et al.,2008).