MicroRNAs，干细胞和癌症干细胞

• 作者: Minal Garg
• 来源期刊: 世界干细胞杂志：英文版（电子版）
• 学科: 医学
• 关键词: STEM cell functions Cancer STEM cells Cellular PATHWAYS MIRNA oncomiR Tumor SUPPRESSOR miRNAs MIRNA based THERAPEUTICS
• 年，卷（期）: 2012,（7）
• 页码范围: 62-70
• 页数: 9页
• 分类号: R329

摘要

This review discusses the various regulatory charac-teristics of microRNAs that are capable of generating widespread changes in gene expression via post translational repression of many mRNA targets and control self-renewal, differentiation and division of cells. It controls the stem cell functions by controlling a wide range of pathological and physiological processes, including development, differentiation, cellular proliferation, programmed cell death, oncogenesis and metastasis. Through either mRNA cleavage or translational repression, miRNAs alter the expression of their cognate target genes; thereby modulating cellular pathways that affect the normal functions of stem cells, turning them into cancer stem cells, a likely cause of relapse in cancer patients. This present review further emphasizes the recent discoveries on the functional analysis of miRNAs in cancer metastasis and implications on miRNA based therapy using miRNA replacement or anti-miRNA technologies in specific cancer stem cells that are required to establish their efficacy in controlling tumorigenic potential and safe therapeutics.