Appearance of attenuated intestinal polyposis during chronic non-steroidal anti-inflammatory drugs use

• 作者: Hugh James Freeman
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: COLON CANCER Duodenal ADENOMA COLON ADENOMA Aspirin NON-STEROIDAL anti-inflammatory drugs ATTENUATED POLYPOSIS Chemoprevention of COLON CANCER
• 年，卷（期）: 2012,（6）
• 页码范围: 100-102
• 页数: 3页
• 分类号: R735.3

摘要

Aspirin and non-steroidal anti-inflammatory drugs (NSAIDS) may prevent sporadic colonic neoplasia and reduce the polyp burden in familial adenomatous polyposis. A 41-year-old pharmacologist with no family history of intestinal polyps or cancer chronically consumed daily aspirin and other non-steroidal anti-inflammatory drugs for decades despite recurrent and multiple gastric ulcers. A cancerous polyp in the colon was endoscopically resected. Over the next 2 decades, almost 50 adenomatous polyps were removed from the rest of his colon and duodenum, typical of an attenuated form of adenomatous polyposis. Chronic and habitual use of aspirin or NSAIDS may have important significance in delaying the appearance of adenomas. The observations here emphasize the important implications for clinical risk assessment in screening programs designed to detect or prevent colon cancer.