The effect of age, gender, level of adiposity and diabetes duration on glycated hemoglobin reduction after anti-diabetic therapy in type-2 diabetic patients

• 作者: Babatunde I. Adejumo Chinwe O. Ewenighi Isaac N. Nnatuanya Joel C. Onyeanusi Linus U. M. Onoh Uchechukwu Dimkpa Uchechukwu Ezeugwu Uzor Simon
• 来源期刊: 糖尿病(英文)
• 学科: 医学
• 关键词: Glycated HEMOGLOBIN Age GENDER ADIPOSITY METFORMIN Diet
• 年，卷（期）: tnbyw,（2）
• 页码范围: 245-250
• 页数: 6页
• 分类号: R5

摘要

Background: It is established that glycemic control measures involving diet and oral medication reduce glycated hemoglobin concentration (HbA1c) in type-2 diabetic patients. Aim: We aimed to determine whether HbA1c reduction after diabetic treatment is affected by age, gender, level of adiposity and diabetes duration in type-2 diabetic patients. Methods: One hundred and four type-2 diabetic patients participated in a 20-week diabetic control therapy involving oral medication (metformin) and lifestyle intervention (diet). We compared the HbA1c reduction after treatment between the elderly and non-elderly;males and females;overweight/obese and non-overweight/obese;and long-standing and newly diagnosed patients. Results: After the treatment, participants had mean HbA1c reduction of 1.1 ± 1.31% and weight loss of 2.46 ± 1.79 kg. Forty-six (44.2%) of the patients had acceptable HbA1c level of p p p < 0.001), respectively. HbA1c reduction did not indicate significant sex differences. Conclusion: The present findings suggest that treatment criteria for type-2 diabetes should account for the age, level of adiposity and diabetes duration of the patient in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.