Endocytosis by target cells: an essential means for perforin-and granzyme-mediated killing
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摘要:
Despite the critical role of cell-mediated immunity in defense against intracellular pathogens,cancer immunosurveillance and development of autoimmunity,the precise mechanisms governing the killing of target cells by cytotoxic T cells (CTLs) and natural killer (NK) cells have remained poorly defined.In a study published in Nature Immunology,Thiery and colleagues have for the first time visualized the movement of the cytotoxic granule proteins perforin and granzymes from the killer cell to the target cell,challenging the textbook model of granulemediated cytotoxicity and providing direct evidence for a multistep endocytosis-mediated mechanism for the entry of granzymes to the target cell's cytoplasm.