MLL-AF4 driven leukemogenesis: what are we missing?
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摘要:
Pre-leukemic MLL-AF4 fusions arise prenatally and typically lead to overt acute iymphoblastic leukemia (ALL) at or shortly after birth.In a recent study,Bueno and colleagues explored the effects of MLL-AF4 expression in human embryonic stem cells (hESCs),with a focus on early hemato-endothelial development.