Synthesis and Crystal Structure of Monocarbonyl Analogs of Curcumin

• 作者: CHEN Xiao-Yan HU Jie LIANG Guang YANG Shu-Lin ZHANG Li ZHAO Cheng-Guang ZHAO Yun-Jie
• 来源期刊: 结构化学
• 学科: 化学
• 关键词: 晶体结构 类似物 姜黄素 合成 椅式构象 电喷雾质谱 晶体学特征 A75
• 年，卷（期）: 2012,（4）
• 页码范围: 491-498
• 页数: 8页
• 分类号: O614.121|TS202.3
• 语种: 英文

摘要

Two monocarbonyl analogs of curcumin containing bis(2,6-difluorobenzyl) were synthesized,and their molecular structures were characterized by 1H NMR,ESI-MS,and X-ray crystallography.In this paper,the crystal structures of these two analogs(A75 and C75) are described and compared with their bis(2-fluorobenzyl) analogues as well as with the available data of curcumin.The cyclopentane rings in A75 have an envelope conformation,while the cyclohexane ring in C75 has a chair conformation.The compounds are symmetrical and the central structure of A75 and C75 connects with two benzylidene rings through E,E-oriented double bonding.