H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2012,（6）
• 页码范围: 427-429
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjs038

摘要

Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus.Recent work has shown that the maternal genome is protected from this remodeling step by an interaction between a modified histone,H3K9me2,and the oocyte-derived factor,PGC7,to prevent oxidation of the maternal DNA by the Tet3 5-methylcytosine oxidase.