Heart healthy=prostate healthy: SELECT, the symbolic end of preventing prostate cancer via heart unhealthy and over anti-oxidation mechanisms?

• 来源期刊: 亚洲男性学杂志（英文版）
• 年，卷（期）: 2012,（2）
• 页码范围: 243-244
• 页数: 2页
• 语种: 英文
• DOI: 10.1038/aja.2011.174

摘要

The Selenium and Vitamin E Cancer Prevention Trial (SELECT) randomized over 35 000 men into four groups:high-dose vitamin E (400 IU day-1),high-dose selenium (200 mcg day-1),combination of vitamin E and selenium,or placebo.1 The brief time period to reach full recruitment was unprecedented;thus,it seemed that participants and health-care professionals were equally eager to test the hypothesis that high-dose antioxidant supplementation could prevent prostate cancer.However,the trial was terminated early,after a median of 5.5 years due to a lack of efficacy,although at the time a non-significant (P=0.06) increased risk of prostate cancer in the vitamin E arm,and type 2 diabetes in the selenium group (P=0.16)were observed.