Synthesis,Characterization and Antitumor Activity in Vitro of Cd（Ⅲ）Complex with Chelidamic Acid

• 作者: CHEN Hua-Jiao HUANG Sheng KANG Jie LI Peng
• 来源期刊: 结构化学
• 学科: 化学
• 关键词: 水热法合成 抗肿瘤活性 HL-60细胞 配合物 体外 表征 K562 HL60细胞
• 年，卷（期）: 2012,（8）
• 页码范围: 1083-1088
• 页数: 6页
• 分类号: O641.4|TQ164.6
• 语种: 英文

摘要

A novel complex [Cd4（HCAM）4（H2O）8] of Cd（Ⅲ） withchelidamic acid （H3CAM） was synthesized by the hydrothermal method and characterized with IR and emission spectra.The crystal structure was determined based on single-crystal X-ray diffraction data.It crystallizes in monoclinic,space group C2/c with a=17.538（5）,b=12.916（4）,c=16.505（7）,β=100.690（14）o,V=3674（2） 3,Z=8,C14 H14 Cd2N2O14,Mr=659.07,Dc=2.383 g/cm 3,μ=2.400 mm-1,S=1.000,F（000）=2560,the final R=0.0242 and wR=0.0581 for 3656 observed reflections with I〉2σ（I）.The inhibition of the complex against K562 and HL60 cells was determined by MTT assay.The results showed that the concentration of complex was positively correlated with inhibitions against K562 and HL60 cell lines,but inhibitory effects are relatively weak.IC 50 concentration of the title complex on K562 and HL60 cells is 15 and 5 μg/mL,respectively.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	HUANG Sheng		1	0	0.0	0.0
2	CHEN Hua-Jiao		1	0	0.0	0.0
3	KANG Jie		1	0	0.0	0.0
4	LI Peng		1	0	0.0	0.0