Synthesis and Structural Features of 3,5-Dihydroxy N′-（3-nitrobenzylidene） Benzohydrazide and Its Effect on the Intestinal Smooth Muscle

• 作者: ARCHANA Bajracharya CHEN Da-Peng DIAO Yun-Peng LIN Yuan WANG Li YE Dong-Mei
• 来源期刊: 结构化学
• 学科: 工学
• 关键词: 苯甲酰肼 二羟基 平滑肌 合成 苄基 硝基 空肠 单晶X-射线衍射
• 年，卷（期）: 2012,（8）
• 页码范围: 1105-1110
• 页数: 6页
• 分类号: TQ453.291|Q445
• 语种: 英文

摘要

A new compound,3,5-dihydroxy-N-（3-nitrobenzylidene）benzohydrazide （DNBB） methanol solvate,was synthesized and characterized by single-crystal X-ray diffraction.DNBB crystallizes in a monoclinic system,space group P2 1/c with a=8.387（4）,b=23.237（10）,c=9.133（3）,β=122.10（3）o,Z=4,V=1507.8（12） 3,D c=1.464 g/cm 3,F（000）=696.0,μ=0.116 mm-1,the final R=0.0480 and wR=0.1294.DNBB exhibited low toxicity on Caco-2 cell culture and produced significant inhibitory effect on the contraction of rat jejunal longitudinal smooth muscle （JLSM）.The mechanism of DNBB on JLSM was correlated to the stimulation of α and β adrenergic receptors since α receptor antagonist phentolamine and β receptor antagonist propranolol abolished the inhibitory effects of DNBB on the contraction of JLSM,respectively.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	DIAO Yun-Peng		2	0	0.0	0.0
2	ARCHANA Bajracharya		1	0	0.0	0.0
3	WANG Li		1	0	0.0	0.0
4	YE Dong-Mei		1	0	0.0	0.0
5	CHEN Da-Peng		1	0	0.0	0.0
6	LIN Yuan		1	0	0.0	0.0