The role of LRRK2 in inflammatory bowel disease

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（7）
• 页码范围: 1092-1094
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.42

摘要

LRRK2 was recently identified as a major susceptibility gene for Crohn's disease (CD) by genome-wide association studies (GWAS).LRRK2 deficiency in mice confers enhanced susceptibility to experimental colitis.In this research highlight,we discuss the current understanding of LRRK2 in the context of colitis,and postulate the future directions.