有在一个猪模型的 n 丁基 cyanoacrylate 的支气管的动脉的 embolization 的安全

• 作者: Akira Ikoma Hiroki Minamiguchi Hiroki Sanda Ichiro Mori Kouhei Nakata Morio Sato Motoki Nakai Nobuyuki Kawai Takami Tanaka Tetsuo Sonomura
• 来源期刊: 世界放射学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Bronchial artery EMBOLIZATION EMBOLIC materials N-BUTYL CYANOACRYLATE Gelatin sponge LIPIODOL
• 年，卷（期）: 2012,（12）
• 页码范围: 455-461
• 页数: 7页
• 分类号: R-332

摘要

AIM: To compare the efficacy and safety of bronchial artery embolization (BAE) with n-butyl cyanoacrylate (NBCA) and gelatin sponge particles (GSPs). METHODS: Six healthy female swine were divided into two groups to be treated with BAE using NBCA-lipiodol (NBCA-Lp) and using GSPs. The occlusive durability, the presence of embolic materials, the response of the vessel wall, and damage to the bronchial wall and pulmonary parenchyma were compared. RESULTS: No animals experienced any major complication. Two days later, no recanalization of the bronchial artery was observed in the NBCA-Lp group, while partial recanalization was seen in the GSP group. Embolic materials were not found in the pulmonary artery or pulmonary vein. NBCA-Lp was present as a bubble-like space in bronchial branch arteries of 127-1240 μm, and GSPs as reticular amorphous substance of 107-853 μm. These arteries were in the adventitia outside the bronchial cartilage but not in the fine vessels inside the bronchial cartilage. No damage to the bronchial wall and pulmonary parenchyma was found in either group. Red cell thrombus, stripping of endothelial cells, and infiltration of inflammatory cells was observed in vessels embolized with NBCA-Lp or GSP. CONCLUSION: NBCA embolization is more potent than GSP with regard to bronchial artery occlusion, and both materials were present in bronchial branch arteries≥100 μm diameter.