Induction of fibroblasts to neurons through adenoviral gene delivery

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（2）
• 页码范围: 436-440
• 页数: 5页
• 语种: 英文
• DOI: 10.1038/cr.2011.185

摘要

Dear Editor,The direct conversion of mouse fibroblasts to neurons [1] was developed while many scientists were interested in neuronal differentiation using induced pluripotent stem cells (iPSCs) [2].This direct reprogramming skips a pluripotent state,making patient- and/or disease-specific cell therapy much faster and more feasible.Recent reports have indicated that mouse or human fibroblasts could be directly converted to a number of different cell types,such as cardiomyocytes,blood progenitor cells,hepatocyte-like cells,neural progenitors and specific dopaminergic neurons [3-9].However,all of the studies in this field have employed the retroviral or lentiviral vector delivery system.