[Objective] The research aimed to analyze variation of the vegetation cover in Poyang Lake area from 1991 to 2005. [Method] Based on Landsat TM remote sensing images of 1991 and 2005 in Poyang Lake area, NDVI dimidiate pixel model was used to calculate vegetation coverage. By transfer matrix, temporal-spatial change of the vegetation cover grade in the area was analyzed. [Result] Vegetation cover in this region overall presented increase trend from 1991 to 2005, and forestry area increased somewhat. But at the same time, farmland area decreased to some extent. Sandlot and bare land also increased slightly. [Conclusion] Governments and relevant departments should reasonably allocate land resources and protect natural ecology environment.