Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（12）
• 页码范围: 1637-1639
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.105

摘要

The potentially life-threatening adverse reactions to Abavacir(ABC),a nucleoside analog reverse transcriptase inhibitor for the treatment of HIV infection,have been known for several years to be limited to individuals expressing the HLA-B*57:01 gene.Why the ABC hypersensitivity syndrome is only seen in HLA-B*57:01-expressing subjects and what the precise mechanisms underlying this intolerance are remain however controversial.A series of recent studies,particularly a study by Illing et al.recently published in Nature,now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs.