Releasing the break on X chromosome inactivation:Rnf12/RLIM targets REX1 for degradation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（11）
• 页码范围: 1524-1526
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.98

摘要

One of the two X chromosomes in cells of female mammals is transcriptionally silenced in a process known as X chromosome inactivation (XCI).Initiation of XCI is regulated by the ubiquitin ligase Rnf12/RLIM,but the mechanisms by which Rnf12/RLIM mediates this process has been a mystery.A recent study by Gontan et al.shows that Rnf12/RLIM targets REX1,an inhibitor of XCI,for proteasomal degradation,providing an answer to this question.