Epithelial self-defense against cancer

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2012,（11）
• 页码范围: 1527-1529
• 页数: 3页
• 语种: 英文
• DOI: 10.1038/cr.2012.69

摘要

It is not clearly understood what happens at the interface between normal and transformed epithelial cells at the first step of carcinogenesis.A recent study reveals that the organized epithelial structure suppresses clonal expansion of transformed cells.Translocation from the epithelium or perturbation of intercellular adhesions may be required for transformed cells to evade the suppressive environments.