Synthesis,Crystal Structure and Cytotoxic Activity of a Zinc（Ⅱ） Complex of the Schiff Base Derived from S-benzyldithiocarbazate

• 作者: LI Qian-Qian LI Su-Zhi QIU Xiao-Yang SHI An-Ran ZHAI Bin
• 来源期刊: 结构化学
• 学科: 化学
• 关键词: 晶体结构 锌离子 细胞毒活性 合成 席夫碱 Schiff碱配体 单晶X-射线衍射 红外光谱特征
• 年，卷（期）: 2012,（4）
• 页码范围: 555-561
• 页数: 7页
• 分类号: O614.121|O614.241
• 语种: 英文

摘要

A novel zinc(Ⅱ) complex of empirical formula,ZnL2(L=anionic forms of S-benzyl-β-N-(2,4-dichlorobenzylidene) hydrazine carbodithioate),has been synthesized and characterized by elemental analysis,IR spectra and single-crystal X-ray diffraction.The crystal belongs to the triclinic system,space group P with a = 9.3168(9),b = 13.0353(13),c = 14.7702(15) ,α = 71.2860(10),= 87.5140(10),γ = 79.4480(10)o,V = 1670.0(3) 3,Z = 2,Mr = 773.93,Dc = 1.539 g/cm3,μ = 1.334 mm-1,F(000) = 784,the final R = 0.0403 and wR = 0.0800 for 4060 observed reflections with I〉2(I).In the crystal structure,the zinc(Ⅱ) complex has a distorted tetrahedral geometry in which the zinc ion is coordinated by the nitrogen and sulfur atoms from two Schiff base ligands,respectively.The preliminary bioassay indicates that the Schiff base and its zinc complex exhibit inhibitory activity against the human gastric cancer cell lines(MKN45) and hepatoma cell lines(HepG2).