Synthesis,Crystal Structure and Bioactivity of a Pd（Ⅱ） Complex with Demethylcantharate and 2,2′-Bipyridine

• 作者: LIN Qiu-Yue SHEN Ling-Li WANG Peng-Peng WANG Yan-Jun ZHAO Yu-Ling
• 来源期刊: 结构化学
• 学科: 化学
• 关键词: 晶体结构 联吡啶 配合物 生物活性 单晶X-射线衍射 合成 Pd 牛血清白蛋白
• 年，卷（期）: 2012,（8）
• 页码范围: 1175-1181
• 页数: 7页
• 分类号: O614.121|O614.33
• 语种: 英文

摘要

A novel crystal with the molecular formula [Pd（DCA）（bipy）]2 [Pd（bipy）Cl2 ]·6.75H2O was formed by PdCl2 with disodium demethylcantharate （Na2 （DCA）,DCA2= 7-oxa-bicyclo[2.2.1]heptane-2,3-bicarboxylate） and 2,2-bipyidine （bipy） through the hydrothermal method.The complex was characterized by elemental analysis and infrared spectroscopy.The structure of the complex was determined by single-crystal X-ray diffraction,which is of triclinic system,space group P1 with a=13.6818（7）,b=14.8426（8）,c=15.0043（8）,α=97.319（3）,β=92.521（3）,γ=105.776（2）°,V=2898.4（3） 3,Dc=1.545 g·cm-3,Z=1,F（000）=1420,S=0.852,the final R=0.0525 and wR=0.1777 for 13634 observer reflections （I〉2σ（I））.The binding reaction of the complex with ct-DNA and bovine serum albumin （BSA） was studied by fluorescence spectroscopy.The results indicated that the complex binds to ct-DNA via the partial intercalation.The binding constant K A of the complex interaction with BSA was 3.98×10 5 L·mol-1 and one binding site would be formed.The antiproliferative activity of the complex against human hepatoma cells （SMMC7721） in vitro is much higher than that of Na 2 （DCA）.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	WANG Peng-Peng		1	0	0.0	0.0
2	WANG Yan-Jun		1	0	0.0	0.0
3	LIN Qiu-Yue		1	0	0.0	0.0
4	SHEN Ling-Li		1	0	0.0	0.0
5	ZHAO Yu-Ling		1	0	0.0	0.0